RTG 2660 Approach Avoidance

The project investigates how the brain decides between approach and avoidance behavior—two fundamental and often opposing action strategies that shape our responses in uncertain or conflicting situations. While approach behavior is typically linked to reward systems, avoidance is primarily governed by fear- and stress-related networks. Central to this research is the question of how these different systems interact within the brain and how rapid switching between them is achieved. A key factor in this process is risk assessment, which determines whether we approach or avoid a given situation. Neuroscientific evidence suggests that connections between the prefrontal cortex, amygdala, and brainstem, as well as coordinated patterns of neural activity, play a crucial role in this decision-making process. The aim of the project is to precisely identify and characterize the underlying neural circuits and their dynamics in animal models. In addition, targeted interventions in these networks are being explored to experimentally shift the balance between avoidance and approach behavior. To this end, advanced methods are used that allow for the precise manipulation and monitoring of brain activity. In the long term, the insights gained are intended to be translated into innovative therapeutic approaches, such as neurofeedback-based interventions. These could be particularly beneficial for conditions associated with excessive avoidance behavior and may open up new avenues for individualized treatment strategies. The project is part of the Research Training Group 2660: Approach- Avoidance, funded by the German Research Foundation.