Resolving pain

Chronic pain is thought to be related to changes in certain brain pathways, particularly in a region of the brainstem called the periaqueductal gray (PAG). However, exactly how these changes contribute to pain is still not fully known. In this research, we combine advanced brain imaging and optogenetics with electrocardiac recordings in mice to better understand how PAG circuits influence both short-term and long-lasting pain. We are especially interested in how pain is shaped by social factors and by learning processes, and how these influences affect the way pain is experienced and reduced. Overall, this work aims to clarify how brainstem circuits help regulate and potentially resolve pain. This project is part of the KFO5001 ResolvePAIN consortium, funded by the German Research Foundation.